Welcome to Michael Eisen’s lab in the Howard Hughes Medical Institute (HHMI) at University of California at Berkeley (UCB) and the Lawrence Berkeley National Lab (LBNL). We are part of the Department of Molecular and Cell Biology of UCB and the Genomics Division of LBNL, and the. We are located in Stanley Hall on the Berkeley campus.Our lab applies computational and experimental genomic approaches to study how genome sequences specify organismal form and function. We are particularly interested in the regulation of gene expression, and focus on how the information that specifies when and where genes are expressed is encoded in genome sequences, the role that regulated gene expression plays in animal development and the response of microbes to their environments, and how variation in and evolution of gene expression contributes to phenotypic variation and the remarkable diversity of life on Earth.This site contains a more detailed description of our research projects, an introduction to members of the lab, reprints of all of our publications, free downloadable and web-based software for the analysis of DNA microarray data and of genome sequences, and other useful links and information.
Read our latest in PLoS Biology and PLoS Genetics:
Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition
Harrison MM, Li X-Y, Kaplan T, Botchan MR, Eisen MB (2011) PLoS Genet7(10): e1002266. doi:10.1371/journal.pgen.1002266
Non-Canonical Compensation of Zygotic X Transcription in Early Drosophila melanogaster Development Revealed through Single-Embryo RNA-Seq
Lott SE, Villalta JE, Schroth GP, Luo S, Tonkin LA, et al. (2011)
PLoS Biol 9(2): e1000590. doi:10.1371/journal.pbio.1000590
Quantitative Models of the Mechanisms That Control Genome-Wide Patterns of Transcription Factor Binding during Early Drosophila Development
Kaplan T, Li X-Y, Sabo PJ, Thomas S, Stamatoyannopoulos JA, et al.
(2011)PLoS Genet 7(2):e1001290.doi:10.1371/journal.pgen.1001290