I’m a third-year graduate student in Mike Eisen’s lab. I’m currently working on a molecular evolution model of transcription factor binding site evolution that attempts to use substitution data to infer the factor’s required affinity for its binding site. I’ve also started thinking about the uses of distantly related genomes in binding site discovery.
Given that I’m fairly lazy on the web site front, I’m patterning my web site on Venky’s web site. In time, it may mature to become more like Lenny’s, and with superhuman effort, a little luck, and a little pluck (and just a pinch of the ol’ TLC), it might resemble Dan’s.
- Characterizing the evolution of gene regulation in fungi
- Developing a theory of the molecular evolution of regulatory sequences
- Identification of regulatory sequences in Drosophila
Eisen Lab Publications:
Lusk RW, Eisen MB. (2008) Use of an evolutionary model to provide evidence for a wide heterogeneity of required affinities between transcription factors and their binding sites in yeast. Pac Symp Biocomput. 2008;:489-500