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Characterizing the evolution of gene regulation in fungi

A large and diverse group of fungi have been sequenced, making them a uniquely suited clade for studying processes and phenomena that may only change over long evolutionary distances.  We were able to use previously identified transcription factor binding affinities to examine dynamics in the regulation of large regulatory systems, from the level of these individual binding site affinities to the level of spacing in promoter structure.  We have also been able to take advantage of S. cerevisiae’s relatively simple regulation to probe the impact in variations of these structures in the lab.  We are currently implementing a graphical model to quantify conservation and systematically identify changes in promoter components.


People:

Annie Tsong
Devin Scannell
Richard Lusk
Genny Gould
Lenny Teytelman